Environmental biomolecular chemistry. With the increase of sustainable practices, the persistence of structural integrity and biological functions of environmental antibiotic resistance genes (ARGs) in the treated water and biosolids is a huge public health concern. The environmental ARGs can be up-taken by the microbes and further develop resistance to antibiotics. We focus on the sunlight photolysis of environmental ARGs in liquid and at the liquid-solid interface to inform the control of antimicrobial resistance. We are developing molecular assays, mass spectrometry analysis, and microbial transformation assays to fully understand the mechanism of nucleic acids photo-reactions in natural environment and the impact of sunlight on antimicrobial resistance development from the environmental ARGs.